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将红霉素产生菌——红色链霉菌的菌丝体经溶菌酶去壁后获得的原生质体 ,用紫外线照射一定时间后 ,在再生培养基上得到再生菌株 ,通过活性测定 ,挑选抑菌圈大而清晰的再生菌株进行摇瓶筛选 ,最后得到比对照菌株效价提高 2 2 5.8%的高产菌株 HP-3
The erythromycin-producing bacteria - Streptomyces ruber mycelium lysozyme to the wall after the protoplast obtained by UV irradiation for a certain period of time, the regeneration medium to obtain regenerated strains, through the determination of activity, inhibition zone Large and clear regenerated strains were shake flask screening, and finally get higher than the control strains titers 2 2 5.8% of high yield strain HP-3