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目的糖化血红蛋白(HbA1c)>9%的新诊断的2型糖尿病患者进行甘精胰岛素或格列美脲联合二甲双胍的短期强化治疗,探讨2种强化方案的疗效。方法 34例新诊断的2型糖尿病随机分为甘精胰岛素组和格列美脲组,每组17例,分别使用甘精胰岛素或格列美脲联合二甲双胍治疗,疗程12周,对其在治疗前后血糖控制情况及胰岛β细胞功能进行自身及组间比较。结果治疗后2组空腹血糖(FPG)、餐后2 h血糖(2 h PG)、HbA1c均显著下降(P均<0.01),胰岛素抵抗指数(HOMA-IR)下降(P<0.05),HOMAβ-升高(P<0.01)。FPG、2 h PG、HbA1c治疗前后的差值及治疗12周后早餐前后血糖差值,2组间比较差异均有统计学意义(P均<0.05),甘精组血糖达标更显著、迅速。结论 HbA1c>9%的新诊断的2型糖尿病患者2种短期强化方案疗效均佳,且甘精组降糖更显著、迅速。
Objective To evaluate the short-term intensive treatment of glargine or glimepiride combined with metformin in patients with newly diagnosed type 2 diabetes mellitus with glycohemoglobin (HbA1c)> 9% and to explore the efficacy of the two intensified regimens. Methods Thirty-four newly diagnosed type 2 diabetes mellitus were randomly divided into insulin glargine group and glimepiride group, 17 patients in each group were treated with insulin glargine or glimepiride combined with metformin for 12 weeks. Before and after the control of blood glucose and pancreatic β-cell function of their own and compared between groups. Results After treatment, fasting blood glucose (FPG), postprandial 2h blood glucose (2h PG) and HbA1c were significantly decreased (P <0.01), HOMA-IR decreased (P <0.05) Increased (P <0.01). FPG, 2 h PG, HbA1c difference before and after treatment and 12 weeks after treatment of breakfast before and after the difference in blood glucose, the difference between the two groups were statistically significant (P all <0.05), Glycerine group more significant and fasting blood glucose. Conclusion Two kinds of short-term intensive treatment regimens with newly diagnosed type 2 diabetes patients with HbA1c> 9% have good curative effect, and the glycemic excretion of Gan Gan group is more and more rapid.