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目的研究乳腺癌患者抵抗素、脂联素、瘦素及血脂变化及临床意义。方法 90例经病理诊断为乳腺癌的患者为病例组,50例与之年龄匹配的健康人群为对照组,测定血清中的抵抗素,脂联素、瘦素、空腹血糖(FBG)及血脂。结果病例组脂联素及高密度脂蛋白胆固醇(HDL-C)显著降低(P<0.01或P<0.05)。病例组抵抗素、瘦素、空腹血糖及甘油三酯均明显增加(P<0.01或P<0.05)。但抵抗素、脂联素及瘦素在乳腺癌患者与健康对照组之间差异无统计学意义(P>0.05)。有淋巴结转移的乳癌患者与无淋巴结转移乳腺癌患者间,抵抗素、脂联素及瘦素差异有统计学意义(P<0.01)。逐步回归分析,脂联素及HDL-C的降低,瘦素和抵抗素的升高将会增加罹患乳癌的风险。血清中脂联素降低和瘦素的增加与乳腺癌患者淋巴结的转移呈现相关性。结论血清中脂联素水平的降低和抵抗素及瘦素水平的升高是乳腺癌患病的危险因素。血清较低的脂联素和较高的瘦素是乳腺癌转移的危险因素。
Objective To study the changes of resistin, adiponectin, leptin and blood lipids in patients with breast cancer and its clinical significance. Methods Ninety patients with pathologically diagnosed breast cancer were selected as the case group. Fifty age - matched healthy subjects were included as control group. Serum levels of resistin, adiponectin, leptin, fasting blood glucose (FBG) and serum lipids were measured. Results In the case group, adiponectin and high density lipoprotein cholesterol (HDL-C) were significantly decreased (P <0.01 or P <0.05). In the case group, resistin, leptin, fasting blood glucose and triglyceride were significantly increased (P <0.01 or P <0.05). However, there was no significant difference between resistin, adiponectin and leptin in breast cancer patients and healthy controls (P> 0.05). There were significant differences in resistin, adiponectin and leptin between patients with lymph node metastasis and those without lymph node metastasis (P <0.01). Stepwise regression analysis showed that the decrease of adiponectin and HDL-C, the increase of leptin and resistin would increase the risk of breast cancer. Decreased serum adiponectin and leptin increased breast cancer patients with lymph node metastasis showed correlation. Conclusions The decrease of serum adiponectin level and the increase of resistin and leptin level are the risk factors of breast cancer. Lower serum adiponectin and higher leptin are risk factors for breast cancer metastasis.