论文部分内容阅读
以舒必利(SUL)为模板分子,甲基丙烯酸(MAA)为功能单体,乙二醇二甲基丙烯酸酯为交联剂,采用本体聚合法合成了舒必利的分子印迹聚合物(MIP),采用静态平衡和等温吸附实验研究了影响MIP性能的各种因素及吸附机理.结果表明,当SUL为0.3mmol时,制备其MIP的优化条件为:乙腈溶剂用量6mL,SUL与MAA的摩尔比为1:4,以甲醇-乙酸(9:1,?)溶液为洗脱剂洗脱;该聚合物结构均匀、疏松,对SUL具有较好吸附性能,最大吸附容量为79.12μmol/g,印迹因子为3.76;初步认为其吸附机理是SUL分子结构中的N-甲基吡咯烷、酰胺和苯磺酰胺基团上的氨基与MAA自组装形成的吸附识别位点空穴;该MIP能识别SUL及其结构类似物阿米舒必利和泰必利,特异性吸附率分别为68.35%,66.72%和58.8%.
The sulpiride molecularly imprinted polymer (MIP) was synthesized by the bulk polymerization method using sulphydryl (SUL) as the template molecule, methacrylic acid (MAA) as the functional monomer and ethylene glycol dimethacrylate as the crosslinking agent. Static equilibrium and isothermal adsorption experiments were carried out to study the various factors affecting the MIP performance and the adsorption mechanism.The results showed that when the SUL was 0.3mmol, the optimal conditions for preparation of MIP were as follows: the amount of acetonitrile solvent was 6mL, the molar ratio of SUL to MAA was 1 : 4, eluted with methanol-acetic acid (9: 1,?) As eluent. The polymer was uniform and loose, and had good adsorption properties to SUL. The maximum adsorption capacity was 79.12μmol / g, 3.76. It is preliminarily considered that the adsorption mechanism is the adsorption recognition site hole formed by the self-assembly of amino groups on N-methylpyrrolidine, amide and benzenesulfonamide groups with MAA in the SUL molecular structure; this MIP can recognize SUL and its The structural analogs amisulpride and tiapride, the specific adsorption rates were 68.35%, 66.72% and 58.8% respectively.