论文部分内容阅读
目的探讨高脂喂养对家兔血脂水平及动脉粥样硬化的影响。方法将23只家兔随机分为二组:A组为高脂喂养组(n=20),B组为正常饲料喂养组(n=3);为对照组。分别于高脂喂养前、喂养后2w、4w、8w和12w取家兔耳缘静脉取血各1次,行血清总胆固醇、甘油三酯、高密度脂蛋白和低密度脂蛋白测定。结果A组高脂喂养2w后血清总胆固醇、甘油三酯、低密度脂蛋白水平较高脂喂养前及对照组均明显升高(P<0.01)。而4w后高密度脂蛋白也明显升高(P<0.01)。结论家兔血脂水平在高脂喂养2-4w即达峰值,并开始下降,而其促动脉粥样硬化作用将延续。
Objective To investigate the effect of high fat diet on serum lipid and atherosclerosis in rabbits. Methods Twenty-three rabbits were randomly divided into two groups: group A was fed with high fat diet (n = 20), group B was fed with normal diet (n = 3); control group. Blood samples were taken from the ear vein of rabbits at 2w, 4w, 8w and 12w after feeding respectively for determination of serum total cholesterol, triglyceride, high density lipoprotein and low density lipoprotein. Results Serum total cholesterol, triglyceride and low density lipoprotein levels of group A were significantly higher than those before high fat diet and control group (P <0.01). After 4 weeks, HDL was also significantly increased (P <0.01). Conclusion Serum lipids in rabbits peaked 2-4 h after high fat diet and began to decline, and the role of atherosclerosis in rabbits continued.