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在血吸虫病以人群化疗为主要防治对策条件下 ,人群再感染规律的研究被认为是血吸虫病流行病学研究的核心问题。研究表明 ,人体的免疫状况与血吸虫再感染有着密切的关系。流行病学研究发现一种与年龄相关的获得性免疫在血吸虫再感染中起重要作用 ,而对抗血吸虫特异抗原的各种抗体在再感染中的作用进行了深入的研究。其次 ,多数研究认为对血吸虫再感染的免疫力的表达可能是同型抗体介导的“效应免疫应答”与“阻断抗体应答”之间动态平衡的结果 ,也有研究着重于各种同型抗体及 Th2类免疫反应的在血吸虫再感染中的作用。
In the case of schistosomiasis population chemotherapy as the main control strategy, the study of the law of population re-infection is considered to be the core issue of epidemiological studies of schistosomiasis. Studies have shown that the human immune status and schistosoma re-infection have a close relationship. Epidemiological studies have found that age-related acquired immunity plays an important role in the re-infection of schistosoma, and the role of various antibodies against the specific antigen of schistosome in re-infection has been studied in depth. Second, most studies suggest that the expression of immunity against reinfection with Schistosoma japonicum may be the result of a homeostasis-mediated dynamic balance between the “effector immune response” and the “blocking antibody response”, as well as the studies focusing on various isotype antibodies and Th2 Role of immunoreactive immune response in the re-infection of schistosomiasis.