Roles of sphingosine-1-phosphate signaling in angiogenesis

• 作 者: Yoh Takuwa Yasuo Okamoto Norik
• 机 构: DepartmentofHealthandMedicalSciences
• 出 处: 世界生物化学杂志：英文版（电子版）
• 发表日期: 2010年10期
• 关键词: Sphingosine-1-phosphate ANGIOGENESIS Angiogenic therapy Rac Akt Vascular MATURAT
• 基金项目: Supported by Grants from the Ministry of Education, Science, Sports and Culture of Japan and the Japan Society for the Promotion of Science,the Practical Application Research program of Japan Science

Sphingosine-1-phosphate (S1P) is a blood-borne lipid mediator with pleiotropic biological activities. S1P acts via the specific cell surface G-protein-coupled receptors, S1P1-5. S1P1 and S1P2 were originally identified from vascular endothelial cells (ECs