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近年来,肺部磨玻璃影(ground-glass opacity,GGO)逐渐得到临床医生关注,GGO多数情况下呈惰性,但也可进一步发展为肺癌。肺多发GGO肺癌大部分为多原发癌(multiple primary lung cancer,MPLC),不是肺内转移癌。对于怀疑为多发GGO肺癌,治疗方式主要为手术切除,同时获得病理诊断,通过不同病灶的驱动基因检测最终明确多原发癌的诊断。手术方式可以选择亚肺叶切除或楔形切除最主要的病灶。研究表明最主要病灶的直径和病灶类型与预后明显相关,而遗留的GGO病灶是否长大、是否出现新的GGO病灶、是否所有的GGO病灶被处理对患者的预后影响小。该文旨在正确评价和处理肺多发GGO肺癌。
In recent years, ground-glass opacity (GGO) has gradually attracted the attention of clinicians. In most cases, GGO is inert, but it can be further developed into lung cancer. Pulmonary multiple GGO lung cancer is mostly multiple primary lung cancer (MPLC), not lung metastasis. For suspected multiple GGO lung cancer, the main treatment for surgical resection, while pathological diagnosis, through the detection of different lesions of the driver finally clear multi-primary cancer diagnosis. Surgery can choose the sub-lobectomy or wedge resection of the most important lesion. Studies have shown that the diameter of the most important lesion and the type of lesion is significantly related to the prognosis, and whether the remaining GGO lesions grow up, whether the emergence of new GGO lesions, whether all GGO lesions are treated on the prognosis of patients with small. This article aims to correctly evaluate and treat lung multiple GGO lung cancer.