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目的研究浙江省部分人群乙肝病毒(HBV)感染与代谢综合征的相关性以及MS的危险因素分析。方法在体检人群中选择丙型肝炎抗体阴性的7774例受检者,分别测量身高、体重、血压、血脂、血糖、肝酶、胰岛素和乙肝标志物等指标。结果 HBsAg阳性检出率8.31%(646例),男性HBsAg阳性组中的ALT、AST、GGT、胰岛素(IRI),HOMA-IR和HOMA-β均高于男性HBsAg阴性组(P<0.01,P<0.05);男性HBsAg阳性组中的TG、TC、UA均显著低于对照组(P<0.05);在女性HBsAg阳性组中仅ALT与对照组有差异(P<0.05);MS发病率为10.13%,男性HBsAg阳性组MS发病率低于男性HBsAg阴性组(11.5%vs 16.67%,P<0.05);女性HBsAg阳性组MS的发病率为4.20%(9/214);女性HBsAg阴性组MS发病率为3.75%,女性组之间没有差异(P>0.05)。患MS的危险因素分别有体重指数(BMI)、年龄、性别、血清胰岛素、TC、TG、UA以及胰岛素抵抗指数(HOMA-IR)。结论 HBsAg感染与MS发病率无相关性,但是与胰岛素抵抗相关。
Objective To study the correlation between hepatitis B virus (HBV) infection and metabolic syndrome in some people in Zhejiang Province and the risk factors of MS. Methods 7774 subjects who were negative for hepatitis C antibody were selected from the physical examination population, and the body height, weight, blood pressure, blood lipid, blood glucose, liver enzymes, insulin and hepatitis B markers were measured. Results The positive rate of HBsAg was 8.31% (646 cases). The levels of ALT, AST, GGT, insulin (IRI), HOMA-IR and HOMA-β in male HBsAg positive group were higher than those in male HBsAg negative group <0.05). The levels of TG, TC and UA in male HBsAg-positive group were significantly lower than those in control group (P <0.05). Only ALT in female HBsAg-positive group was significantly different from that in control group (P <0.05) The incidence of MS in male HBsAg positive group was lower than that in male HBsAg negative group (11.5% vs 16.67%, P <0.05). The incidence of MS in female HBsAg positive group was 4.20% (9/214) The incidence was 3.75%, there was no difference between the female group (P> 0.05). Risk factors for MS were body mass index (BMI), age, sex, serum insulin, TC, TG, UA and insulin resistance index (HOMA-IR). Conclusion HBsAg infection has no correlation with the incidence of MS, but is related to insulin resistance.