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目的:观察米非司酮联合地佐辛复合异丙酚在人工流产术中的应用效果。方法:360例自愿终止妊娠的初孕妇女随机分为4组,观察各组镇静镇痛效果,宫颈软化效果,扩张宫颈的时间,子宫收缩情况,术中出血量,人工流产综合征发生情况,人工流产术近期并发症。结果:A组、C组(地佐辛镇痛组)镇痛效果满意;B组、D组(芬太尼镇痛组)镇痛效果欠佳,总不良反应发生率地佐辛组明显低于芬太尼组(P<0.05)。A组、B组(米非司酮软化宫颈组)总有效率达100%,充分软化率与C组、D组(空白组)相比有明显统计学差异(P<0.01),但人工流产近期并发症的观察未见统计学差异。结论:镇痛效果优良,宫颈软化率高,扩张宫颈快捷安全,未见人工流产综合征的发生。
Objective: To observe the effect of mifepristone and dezocine combined with propofol in artificial abortion. Methods: 360 pregnant women with voluntary termination of pregnancy were randomly divided into 4 groups. The sedation analgesic effect, cervical softening effect, cervical dilatation, uterine contractions, intraoperative blood loss and abortion syndrome were observed. Recent complications of induced abortion. Results: The analgesic effect was satisfactory in group A and group C (dezocine analgesia group). The analgesic effect of group B and group D (fentanyl analgesia group) was poor, and the total adverse reaction rate was significantly lower in dezocine group Fentanyl group (P <0.05). The total effective rate was 100% in group A and group B (mifepristone softening cervical group), and the full softening rate was significantly different from those in group C and group D (blank group) (P <0.01) The recent complication of the observation no significant difference. Conclusion: The analgesic effect is excellent, the cervical softening rate is high, the cervical dilatation is quick and safe, and no abortion syndrome occurs.