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摘要目的评估CT引导下间断(IRT)高剂量(HDR)近距离放疗(BRT)在无法切除的原发性和继发性肝恶性肿瘤的疗效,本文更新和扩展了我们先前描述该治疗方法的经验。方法 41例共50个肝门部或胆管分叉附近肿瘤,59次行CT引导下IRT HDR BRT治疗。肿瘤直径均>4 cm,体积中位数为84 cm3(38~1 348 cm3)。IRT HDR BRT释放的中等物理总剂量约20.0 Gy(7.0~32.0 Gy),19例病人每天2次,每次约7.0 Gy(4.0~10.0 Gy),22例每天1次约8.0 Gy(7.0~14.0 Gy)。
Abstract Objective To evaluate the efficacy of CT-guided high-dose (HDR) brachytherapy (BRT) in unresectable primary and secondary hepatic malignancies. This article updates and expands our previous work on this treatment experience. Methods A total of 41 cases of hilar or bile duct near the tumor in 41 cases, CT-guided 59 cases of IRT HDR BRT treatment. Tumors were> 4 cm in diameter with a median volume of 84 cm3 (38-1 348 cm3). The median total dose of IRT HDR BRT released was about 20.0 Gy (7.0-32.0 Gy), 19 patients were treated with 7.0 Gy (4.0-10.0 Gy) twice daily and 8.0 Gy Gy).