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目的 探讨细菌性阴道炎 (bacterialvaginosis,BV)与女性免疫性不孕的关系。方法 通过检测不孕妇女的抗精子抗体 (AsAb)、抗子宫内膜抗体 (EmAb)及抗心磷脂抗体 (ACA) ,分析细菌性阴道炎与免疫性不孕抗体的相关性。结果 经统计学分析各组间阳性率比较 ,血清AsAb ,BV不孕组与非BV不孕组相比显著增高 (P <0 0 5 ) ;宫颈粘液AsAb、EmAb、ACA等 ,BV不孕组与非BV不孕组相比均有极显著差异 (P <0 0 1) ;不孕组均高于健康孕妇对照组 (P <0 0 1)。BV与三种抗体的相关性 :BV感染阳性与血清AsAb、宫颈粘液AsAb阳性相关分析均P <0 0 5 ,BV与其他抗体相关分析均P >0 0 5。结论 BV与免疫性不孕的形成和发展有一定的关系 ,尤其是与AsAb的产生有相关性 ,致使反复自然流产增加。
Objective To investigate the relationship between bacterial vaginosis (BV) and female infertility. Methods The relationship between bacterial vaginosis and immune infertility antibodies was analyzed by detecting AsAb, EmAb and ACA in infertile women. Results The positive rates of AsAb and BV in serum were significantly higher than those in non-BV infertility group (P <0.05) by statistical analysis of the positive rates among the groups. AsAb, EmAb and ACA in cervical mucus, Compared with the non-BV infertility group, there was significant difference (P <0.01); the infertility group was higher than the healthy pregnant women control group (P <0.01). The correlation between BV and three kinds of antibodies: BV infection positive and serum AsAb, cervical mucus AsAb positive correlation analysis P <0 05, BV and other antibodies were P> 0.05. Conclusion BV has some relationship with the formation and development of immune infertility, especially with the production of AsAb, resulting in the increase of recurrent spontaneous abortion.