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非甾类抗炎药(NSAIDs)已在全世界广泛应用.本文综述了了与NSAIDs应用有关的胃肠道、肝、肾、血液和过敏反应的流行病学资料.Meta-Analysis研究表明,NSAIDs和严重的上消化道病变有关.与不服用NSAIDs患者相比,用NSAIDs病人发生上消化道病变的相对危险度(RR)为2.7,增大用药剂量、延长用药时间以及60岁以上患者应用NSAIDs时,导致上消化道病变的危险度相应增加.现有资料已强烈支持NSAIDs和胃肠道病变之间的因果关系.同时.病例对照研究表明NSAIDs和中性粒细胞减少存在一定的联系.使用NSAIDs患者较未该
Non-steroidal anti-inflammatory drugs (NSAIDs) have been widely used in the world.This paper reviews the epidemiological data of gastrointestinal tract, liver, kidney, blood and allergic reactions related to the use of NSAIDs.Meta-Analysis showed that NSAIDs And severe upper gastrointestinal lesions.Compared with non-NSAIDs patients, NSAIDs patients with upper gastrointestinal lesions relative risk (RR) of 2.7, increasing the dose, to extend the medication time and the age of 60 patients with NSAIDs There is a corresponding increase in the risk of upper gastrointestinal lesions.The available data strongly support the causal relationship between NSAIDs and gastrointestinal lesions.Meanwhile, case-control studies have shown that there is a certain relationship between NSAIDs and neutropenia. NSAIDs patients more than the