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转化生长因子(TGF—β)是一类具有多种生物学活性的细胞因子,其结构和受体有较多的研究,但其生物学效应途径至今尚无统一认识。TGF—β的生物学作用主要是参与炎症反应,促进成骨细胞活跃,诱导胶原蛋白合成,使损伤组织得以修复。在根尖周炎中,TGF—β作用于牙周膜纤维细胞,使DNA合成量增加,碱性磷酸酶活性增高,加快纤维性愈合和硬组织的形成过程,从而有利于慢性根尖周炎的修复和治愈。最后展望了细胞生长因子在口腔炎性疾病中的病理生理机制的研究,使之对炎性疾病的本质有一个更新的认识。
Transforming growth factor (TGF-β) is a class of cytokines with a variety of biological activities, and its structure and receptor have more research, but its biological effects of the path so far there is no uniform understanding. The biological role of TGF-β is mainly involved in the inflammatory response, promote osteoblast activity, induce collagen synthesis, so that damaged tissue can be repaired. In periapical periodontitis, TGF-β acts on periodontal ligament fibroblasts to increase DNA synthesis, increase alkaline phosphatase activity and accelerate the process of fibrous healing and hard tissue formation, which is good for the repair of chronic apical periodontitis And cure. Finally, the research on the pathophysiological mechanism of cell growth factor in oral inflammatory diseases is made, which brings a new understanding of the nature of inflammatory diseases.