Lactate Promotes Cancer Stem-like Property of Oral Sequamous Cell Carcinoma

• 作 者: Hui ZHAO Chuan-yu HU Wei-min C
• 机 构: DepartmentofStomatology
• 出 处: 当代医学科学(英文)
• 发表日期: 2019年3期
• 关键词: ORAL SQUAMOUS cell carcinoma LACTATE CANCER STEM cells organoid monocarboxylate
• 基金项目: This project was supported by the National Natural Science Foundation of China (No.81602742).

Accumulation of lactate in tumor has been linked to poor prognosis of oral squamous cell carcinoma (OSCC), but the underlying mechanism remained largely uncertain. Previous studies have suggested that presence of cancer stem cells (CSCs) closely correlate