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目的 探讨血清白细胞介素 8(IL8)变化在小儿急性淋巴细胞白血病中的意义。方法 采用夹心酶联免疫吸附法检测 46例急性淋巴细胞白血病患儿血清中IL8水平。结果 急性淋巴细胞白血病 (ALL)患儿治疗前IL8水平显著高于正常对照组 ;ALL患儿治疗有效者IL8水平显著下降 ,无效者仍保持高水平 ,完全缓解时与正常对照组无差异。治疗前IL8水平在无反应者显著高于有反应者。结论 IL8水平的变化可作为ALL的病情及监测治疗反应的一种手段。
Objective To investigate the significance of serum interleukin 8 (IL8) in children with acute lymphoblastic leukemia. Methods Serum IL-8 levels were measured by sandwich enzyme-linked immunosorbent assay in 46 children with acute lymphoblastic leukemia. Results The levels of IL8 in children with acute lymphoblastic leukemia (ALL) before treatment were significantly higher than those in normal controls. The levels of IL8 in children with ALL were significantly decreased, but those with ineffectiveness remained high. There was no difference between the two groups in complete remission. IL8 levels before treatment were significantly higher in responders than those in responders. Conclusion The change of IL8 level can be used as a means to monitor the response of ALL patients.