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研究表明,中枢多巴胺与阿片类物质之间存在着复杂的神经调节关系。一般将多巴胺和阿扑吗啡能够促进离体脑薄片脑啡肽的释放与多巴胺受体拮抗剂阻滞此效应视为体内存在着一种局部多巴胺激活的环路,在促进纹状体中间神经元释放脑啡肽的同时,后者又对多巴胺神经未梢起反馈作用。因而,只要能直接作用于多巴胺末梢或者通过影响脑啡肽能中间神经元活动的药物,均可影响多巴胺能活动。非哌西特[Fipexide,(氯-4-苯)-2-乙酰基-1-甲二氧基3,4-苄基-4-哌嗪]是一种新的治疗老年性认识功能障碍的化合物,有轻微激活多巴胺能传递的作用。本文研究非哌西特和释放儿茶酚胺的药物苯丙胺对离
Studies have shown that there is a complex neuromodulation relationship between central dopamine and opioids. Generally, dopamine and apomorphine can promote the release of enkephalin in isolated brain slices and the blockade of dopamine receptor antagonists. This effect is considered as a local loop of dopamine activation in vivo, which promotes the activation of striatal interneurons At the same time of releasing enkephalin, the latter has a feedback effect on dopamine nerve tip. Thus, dopamine activity can be affected as long as the drug can act directly on the dopamine terminal or affect the activity of enkephalin interneurons. Fipexide (chloro-4-phenyl) -2-acetyl-1-methylendioxy-3,4-benzyl-4-piperazine] is a new treatment for senile cognitive dysfunction The compound, which has a slightly activated dopaminergic effect. This article studies the release of amphetamine from non-piceat and catecholamines