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Purpose:To investigate and compare the latency and amplitude of the electroretinogram(ERG)photopic negative response (PhNR) between young and old Lewis rats.Methods:Thirteen Lewis rats were divided into two groups according to ages,young group (3-month old,n=5) and old group (24 month old,n=8).The ERGs of the left eyes were measured and the latency and amplitude of a-wave,b-wave and PhNRs were recorded and compared according to ages.The mean values between two groups were statistically analysed by t-test.Results:The latency of PhNRs was evidently prolonged in old group and showed significant difference(P＜0.05).There was no statistically significant difference between two groups regarding the amplitude and latency,and no significant difference was noted in the amplitude of PhNRs.Conclusion:The prolonged latency of PhNR in aged rats possibly associate with the influence of aging upon retinal ganglion cell layer (RGCL).