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Plants have evolved and diversified to reduce the damages imposed by infectious pathogens and herbivorous insects.Living in a sedentary lifestyle,plants are constantly adapting to their environment.They employ various strategies to increase performance and fitness.Thus,plants developed cost-effective strategies to defend against specific insects and pathogens.Plant defense,however,imposes selective pressure on insects and pathogens.This selective pressure provides incentives for pathogens and insects to diversify and develop strategies to counter plant defense.This results in an evolutionary arms race among plants,pathogens and insects.The ever-changing adaptations and physiological alterations among these organisms make studying plant-vector-pathogen interactions a challenging and fascinating field.Studying plant defense and plant protection requires knowledge of the relationship among organisms and the adaptive strategies each organism utilize.Therefore,this review focuses on the integral parts of plant-vectorpathogen interactions in order to understand the factors that affect plant defense and disease development.The review addresses plant-vector-pathogen co-evolution,plant defense strategies,specificity of plant defenses and plant-vector-pathogen interactions.Improving the comprehension of these factors will provide a multi-dimensional perspective for the future research in pest and disease management.