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Dear Editor,Host chaperone proteins are critical factors in plant virus infection.One of the most commonly identified host factors involved in plant virus infection is Hsp70,which functions in ATP hydrolysis,protein folding,assembly of protein complexes,and translocation between cellular compartments.A comparative study of plant virus infection,including Potato virus X (PVX),reported that Hsp70 is up-regulated by virus infection and possibly contributes to pathogenesis in both Arabidopsis and N.benthamiana plants (Aparicio et al.,2005).Cytosolic Hsp70 interacts with the tombusvirus and tymovirus replication complexes (Wang et al.,2009),the potyvirus coat protein (Hafren et al.,2010),and closteroviruses encode an HSP70 homolog that functions to enable virus intercel lu lar transport (Agranovsky et al.,1998).