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目的分析慢性乙型肝炎患者外周血CD4~+CD25~+调节性T细胞(Treg)表达频率检测的临床意义。方法采集48例慢性乙型肝炎患者和32例健康人的外周血,检测CD4~+CD25~+调节性T细胞频率,以及CD3~+/CD4~+/CD8~+淋巴细胞百分比,分析检测结果在慢性乙型肝炎患者和健康人群中的差异。结果慢性乙型肝炎组CD4~+CD25~+Treg细胞百分比高于对照组,差异有统计学意义(t=3.256,P<0.05)。CD3~+/CD4~+/CD8~+淋巴细胞百分比在慢性乙型肝炎组和对照组组间比较差异均无统计学意义(t值分别为2.071、1.985、1.424,P>0.05)。结论慢性乙型肝炎患者外周血CD4~+CD25~+调节性T细胞百分比升高,CD3~+/CD4~+/CD8~+淋巴细胞百分比变化不大。因此慢性乙型肝炎患者测定CD4~+CD25~+调节性T细胞百分比更有意义。
Objective To analyze the clinical significance of detecting the frequency of CD4 ~ + CD25 ~ + regulatory T cells (Tregs) in peripheral blood of patients with chronic hepatitis B (HBV). Methods The peripheral blood of 48 patients with chronic hepatitis B and 32 healthy controls were collected to detect the frequency of CD4 ~ + CD25 ~ + regulatory T cells and the percentage of CD3 ~ + / CD4 ~ + / CD8 ~ + lymphocytes. Differences in Chronic Hepatitis B Patients and Healthy Populations. Results The percentage of CD4 ~ + CD25 ~ + Treg cells in chronic hepatitis B group was significantly higher than that in control group (t = 3.256, P <0.05). There was no significant difference in the percentage of CD3 ~ + / CD4 ~ + / CD8 ~ + lymphocytes between the chronic hepatitis B group and the control group (t = 2.071,1.985,1.424, P> 0.05). Conclusion The percentage of CD4 ~ + CD25 ~ + regulatory T cells in peripheral blood of patients with chronic hepatitis B is increased, while the percentage of CD3 ~ + / CD4 ~ + / CD8 ~ + lymphocytes does not change much. Therefore, the determination of patients with chronic hepatitis B CD4 ~ + CD25 ~ + regulatory T cells more meaningful.