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作者用被动血凝试验对194例肾脏疾病患者和39名对照者,测定血清中抗肾小球基底膜和抗肾小管基底膜抗体的存在。结果:7％的肾脏疾病患者循环中同时具有抗肾小球和肾小管基底膜抗体(滴度1:16～1:64);对照者的结果始终阴性。阳性结果的患者有局灶性肾小球肾炎、弥漫性增生性肾小球肾炎或伴有主要血管病变的肾病,例如结节性多动脉炎、血栓性微血管病和肾皮质坏死。用免疫萤光法检查,在1例局灶性肾小球肾炎和1例增生性肾小球肾炎患者中可见免疫球蛋白G(IgG)和补体成分C3的线形沉积物。只有在这2例患者中,显示血凝抗肾小球基底膜抗体对肾小球基底膜有高度的亲和力。
Using passive hemagglutination test 194 cases of kidney disease patients and 39 controls were measured serum anti-glomerular basement membrane and anti-tubular basement membrane antibodies. RESULTS: Seven percent of patients with kidney disease had both anti-glomerular and tubular basement membrane antibodies (titer 1: 16-1: 64) in the circulation, and the controls were negative all the time. Patients with positive results are focal glomerulonephritis, diffuse proliferative glomerulonephritis, or nephropathies associated with major vascular pathologies such as polyarteritis nodosa, thrombotic microangiopathy and renal cortical necrosis. Immunofluorescence staining revealed linear deposits of immunoglobulin G (IgG) and complement component C3 in 1 patient with focal glomerulonephritis and 1 patient with proliferative glomerulonephritis. Only in these 2 patients showed that the hemagglutination anti-glomerular basement membrane antibodies have a high affinity for the glomerular basement membrane.