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背景:原发性高血压患者普遍存在胰岛素抵抗(insulinresistance,IR),因而增加了发生冠心病的危险性,中药制剂对原发性高血压患者IR的水平有何影响?目的:探讨中药制剂益脉降压流浸膏对老年气虚血瘀证型Ⅱ期原发性高血压患者IR的影响。设计:病例-对照研究。地点和对象:治疗组(n=40)来源于济南军区总医院符合1999年世界卫生组织制定的高血压诊断标准,同时符合中国中西医结合研究会制定的中医虚证辨证标准及血瘀证诊断标准辨证属气虚血瘀证型的高血压患者,对照组(n=30)为同期来济南军区总医院健康体检者,无原发性高血压、糖尿病等疾病。实验指标测定在济南军区总医院中心实验室进行。干预:治疗组口服益脉降压流浸膏(药物组成:生黄芪、党参、黄精、当归、川芎、生蒲黄、穿山龙等,每毫升含生药2.0g,由山东济南宏济堂制药有限责任公司提供,批号:991218),10mL/次,3次/d。疗程为8周。分别采用葡萄糖氧化酶法及放射免疫法测定治疗组治疗前后的空腹血糖、空腹血浆胰岛素(fastingplasmainsulin,FPI),计算其胰岛素敏感性指数(insulinsensitivityindex,ISI),并与对照组的空腹血糖、FPI、ISI进行比较。结果:治疗组治疗前空腹血糖犤(4.97±0.61)mmol/L犦与对照组比较,差异无显著性意义(t=1.131,P>0.05);FPI犤(13.71±4.79
BACKGROUND: The prevalence of insulin resistance (IR) in patients with essential hypertension increases the risk of coronary heart disease (CHD). What is the effect of traditional Chinese medicine on IR in patients with essential hypertension? OBJECTIVE: Effect of Pulse Antihypertensive Fluid Extract on IR in Elderly Patients with Hypertension Type Ⅱ of Old Qi Syndrome with Blood - Stasis Syndrome. Design: Case-control study. Location and Subjects: The treatment group (n = 40) from the Jinan Military Region General Hospital met the diagnostic criteria for hypertension developed by the World Health Organization in 1999 and at the same time fulfilled the standard of TCM syndrome differentiation and diagnosis of blood stasis established by the China Association for Integrative Medicine Standard dialectics is a type of hypertensive patients with Qi-deficiency and Blood-stasis syndrome, and the control group (n = 30) is a healthy physical examination of General Hospital of Jinan Military Region in the same period, with no underlying diseases such as hypertension and diabetes. Experimental indicators measured in Jinan Military Region General Hospital Central Laboratory. Intervention: The treatment group oral Yimai antihypertensive flow extract (drug composition: Health Astragalus, Codonopsis, Polygonatum, Angelica, Chuanxiong, raw Puhuang, Daisen, etc., containing 2.0g crude drug per milliliter by Shandong Jinan Hong Jitang Pharmaceutical Co., Ltd. Provided by the company, lot number: 991218), 10mL / time, 3 times / d. The course of treatment is 8 weeks. Fasting plasma glucose (FPI) and fasting plasma protein (FPI) before and after treatment were measured by glucose oxidase method and radioimmunoassay respectively. Insulin sensitivity index (ISI) was calculated and compared with fasting plasma glucose, FPI, ISI for comparison. Results: There was no significant difference in fasting blood sugar level (4.97 ± 0.61) mmol / L before treatment between the treatment group and the control group (t = 1.131, P> 0.05); FPI 犤 (13.71 ± 4.79