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目的了解佛山市先天性甲状腺功能减低症的发病率、分布特点及治疗随访情况,以促进佛山市新生儿疾病筛查工作更好开展。方法分析佛山市2007年1月至2009年6月期间新生儿先天性甲状腺功能减低症(CH)的筛查结果及治疗随访情况,筛查阳性病例采用化学发光法检测血清中游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)及促甲状腺激素(TSH)水平,确诊病例按疾病诊疗常规进行治疗和随访。结果共筛查169 530例新生儿,确诊先天性甲状腺功能减低症73例,发病率1/2322,确诊年龄为10～30天,平均14.5天,发病患儿以暂住人口所生子女居多,以禅城及南海两区居多,确诊者立即开始治疗,并定期至筛查中心进行随访。结论通过新生儿筛查可早期诊断先天性甲状腺功能减低症,并早期进行治疗随访,减少患儿智力低下的发生,提高人口素质。
Objective To understand the incidence, distribution and follow-up of congenital hypothyroidism in Foshan to promote the screening of neonatal diseases in Foshan City. Methods The screening results and treatment follow-up of congenital hypothyroidism (CH) in neonates between January 2007 and June 2009 were analyzed. Chemiluminescence was used to detect serum free triiodothyronine (FT3), free thyroxine (FT4) and thyroid-stimulating hormone (TSH). The confirmed cases were treated and followed up according to the routine diagnosis and treatment. Results A total of 169 530 newborns were screened and 73 cases of congenital hypothyroidism were diagnosed with a morbidity of 1/2322. The diagnosed age ranged from 10 to 30 days (mean, 14.5 days). Most children born to temporary residents had the most children, To Chancheng and the South China Sea are mostly two, the diagnosis of patients immediately began treatment, and regularly to the screening center for follow-up. Conclusion Neonatal screening can be used to diagnose congenital hypothyroidism early, and early treatment follow-up, reduce the incidence of mental retardation in children, improve population quality.