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目的:探讨甲状腺摄碘率和n 99Tcn m显像与Graves甲亢n 131I治疗疗效的相关性。n 方法:回顾性分析132例Graves甲亢患者，按甲状腺24 h摄碘率分为A组(≤50%)、B组(50%~80%)、C组(≥80%)，按照摄碘率曲线趋势分为高峰前移组(6 h/24 h摄碘率比值>1)和无高峰前移组(6 h/24 h摄碘率比值≤1)，根据甲状腺n 99Tcn m显像质量分为1组(≤30 g)、2组(30~60 g)、3组(≥60 g)。比较不同类型分组患者n 131I治疗效果。n 结果:132例患者首次n 131I治疗后随访6个月，总有效率为88.6%(117/132)，总治愈率为78.0%(103/132)，未愈率为22.0%(29/132)。三组不同24 h摄碘率患者治疗后血清甲状腺素水平均较治疗前明显降低(n P均<0.05)，甲状腺24 h摄碘率越低，治疗后血清总三碘甲状腺原氨酸(TT3)、总甲状腺素(TT4)、游离三碘甲状腺原氨酸(FT3)和游离甲状腺素(FT4)水平降低越显著，促甲状腺激素(TSH)升高越明显，治疗效果越明显，各组间比较，差异均有统计学意义(n P均<0.05)。高峰前移组治愈率(13/29，44.8%)明显低于无高峰前移组(90/103，87.4%)，差异有统计学意义(χn 2＝23.899，n P<0.001)。三组不同甲状腺n 99Tcn m显像质量分组患者治愈率比较，差异均有统计学意义(χn 2＝15.502，n P1) and non-peak advance group (6 h/24 h iodine uptake rate ratio≤1). Thyroidn 99Tcn m imaging was divided into three groups according to quality, including group 1 (≤30 g), group 2 (30-60 g) and group 3 (≥60 g). The therapeutic effects of n 131I in different types of patients were compared.n Results:132 patients were followed up for 6 months after the first n 131I treatment. The total effective rate, total cure rate and uncured rate were 88.6%(117/132), 78.0%(103/132), 22.0%(29/132), respectively. The serum thyroxine levels of patients with different 24-h iodine uptake rates in the three groups after treatment were significantly lower than those before treatment (n P<0.05). The lower the 24-h iodine uptake rate of thyroid, the more significantly the serum total triiodothyronine (TT3), total triiodothyronine (TT4), free triiodothyronine (FT3) and free thyroxine (FT4) levels decreased after treatment, the more obvious the increase of thyroid stimulating hormone (TSH), and the more obvious the treatment effect (n P<0.05). The cure rate (13/29, 44.8%) in the peak advance group was significantly lower than that in the non peak advance group (90/103, 87.4%), with statistically significant difference (χn 2=23.899, n P<0.001). There was significant difference in the cure rate among the three groups with different thyroidn 99Tcn m imaging quality (χn 2=15.502, n P<0.001).n Conclusions:With the increase of thyroid mass, the higher the 24-h iodine intake rate, the more obvious the peak shift, the lower the cure rate, the higher the non-healing rate, and the lower the incidence of hypothyroidism.