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目的:合成穿心莲内酯糖苷衍生物。方法:对穿心莲内酯的羟基进行糖苷化,合成了穿心莲内酯-葡萄糖苷,穿心莲内酯-半乳糖苷,穿心莲内酯-甘露糖苷。结果与结论:目标化合物经IR、HNMR、MS得到结构确证,可能具有更强的抗艾滋病的潜力。
Objective: To synthesize andrographolide glycoside derivatives. Methods: The hydroxyl of andrographolide was glycosylated. Andrographolide-glucoside, andrographolide-galactoside, andrographolide-mannosid were synthesized. RESULTS AND CONCLUSION: The target compounds were structurally confirmed by IR, HNMR and MS and may have stronger anti-AIDS potential.