论文部分内容阅读
摘要目的拟表型额颞叶痴呆(phFTD)是一种罕见的且目前知之甚少的临床综合征。phFTD表现为核心行为变异FTD(bvFTD)综合征,不伴有相关的认知缺失及常规颅脑MRI影像的异常,且无进展性。相对于phFTD,已经在bvFTD中发现功能连接和白质(WM)微结构的异常。本研究假设phFTD与bvFTD归属于相同的疾病谱系,并且研究phFTD中是否存与bvFTD相似的功能连接和白质微结构改变。方法不伴有进展性或者其他精神症状的7例phFTD病人,12例
Abstract Objective To investigate the clinical effect of tetralopathic frontotemporal lobe dementia (phFTD), a rare clinical syndrome that is not yet known. The phFTD manifests itself as a core behavioral variant FTD (bvFTD) syndrome without associated cognitive impairment and abnormalities in conventional craniocerebral MRI images, with no progression. Aberrations in functional connectivity and white matter (WM) microstructure have been found in bvFTD relative to phFTD. This study hypothesized that phFTD and bvFTD belonged to the same disease lineage and that phFTD was involved in the functional connectivity and white matter microstructure alteration similar to bvFTD. Methods Seven patients with phFTD without progressive or other psychiatric symptoms, 12 patients