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有关抗生素影响免疫系统最早的论文是Munoz 和 Geister 在30年前发表的。他们发现金霉素在体外可消除正常人白细胞对白色葡萄球菌的吞噬作用。虽然有人反对他们研究所采用的方法,但这一发现表明确实需要进一步弄清常用抗生素对细胞和体液免疫的作用。本文复习了某些常用抗生素在体内外对人和动物的趋化性、淋巴细胞转化、迟发性超敏反应和抗体生成的影响。趋化性趋化性是吞噬细胞通过包括细菌产物、组织蛋白酶和补体成分在内的许多因子附着到致病微生物上的靠拢过程。Goodhart 等发现治疗浓度的艮他霉素在体
The earliest papers on antibiotics affecting the immune system were published by Munoz and Geister 30 years ago. They found that chlortetracycline abolishes the phagocytosis of Staphylococcus aureus by normal human leukocytes in vitro. While some are opposed to the methods they used in their research, this finding suggests that there is a real need to further clarify the effects of commonly used antibiotics on cellular and humoral immunity. This article reviews the effects of some commonly used antibiotics on human and animal chemotaxis, lymphocyte transformation, delayed hypersensitivity and antibody production in vitro and in vivo. Chemotaxis is the process by which phagocytes attach to pathogenic microorganisms through a number of factors, including bacterial products, cathepsins and complement components. Goodhart et al found that the therapeutic concentration of gentamicin in the body