,Costunolide alleviates HKSA-induced acute lung injury via inhibition of macrophage activation

• 作 者: Yun-tian Chen Yao Du Bo Zhao Li-xing Gan Kai-kai Yu Lei Sun Jian Wang Feng Qian
• 机 构: Department of Respiratory Medicine, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University
• 出 处: 中国药理学报（英文版）
• 发表日期: 2019年8期
• 关键词: Costunolide Staphylococcus aureus pneumonia macrophage MAPK signaling

Staphylococcus aureus (S.aureus) infection leads to a severe inflammatory response and causes acute lung injury (ALl),eventually threatening human life.Therefore,it is of importance to find an agent to inhibit inflammation and reduce ALl.Here,we found that costunolide,a sesquiterpene lactone,displays anti-inflammatory effects and ameliorates heat-killed S.aureus (HKSA)-induced pneumonia.Costunolide treatment attenuated HKSA-induced murine ALl in which pulmonary neutrophil infiltration was inhibited,lung edema was decreased,and the production of pro-inflammatory cytokines was significantly reduced.In addition,costunolide dose-dependently inhibited the generation of IL-6,TNF-α,IL-1β,and keratinocyte-derived cytokine (KC),as well as the expression of iNOS,in HKSA-induced macrophages.Furthermore,costunolide attenuated the phosphorylation of p38 MAPK and cAMP response element-binding protein (CREB).Collectively,our findings suggested that costunolide is a promising agent for alleviating bacterialinduced ALl via the inhibition of the MAPK signaling pathways.