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为探讨 ｐ53基因突变和ｃ -ｅｒｂＢ - 2基因扩增在大肠腺癌及其癌前病变中的变化规律 ,本文应用免疫组化方法检测了上述基因在大肠腺癌、绒毛状腺瘤和腺瘤恶变组织中的表达状态 ,并结合随访资料分析其预后意义。1 材料与方法1.1 病例观察收集我院 1992～ 1998年间病理科存档
To investigate the changes of p53 gene mutation and c-erbB-2 gene amplification in colorectal adenocarcinoma and its precancerous lesions, we used immunohistochemistry to detect these genes in colorectal adenocarcinoma, villous adenoma, and adenoma. The expression status of malignant tissue and its follow-up data were used to analyze its prognostic significance. 1 Materials and Methods 1.1 Case observations collected in our hospital from 1992 to 1998