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目的探讨帕金森病伴发抑郁症状的临床特点、影响因素、治疗方法及效果。方法选取本院收治的37例帕金森病伴发抑郁症状的患者,对其临床资料进行回顾性分析,分析抑郁的发生率及特点,抑郁与年龄、性别、病程、UPDRSIII评分及Hoehn-Yahr分级的相关性,采用盐酸舍曲林片联合中药进行治疗,比较治疗前后HAMD评分的变化。结果观察期间86例帕金森病患者中37例具有抑郁症状,发生率为43.02%,主要表现为对工作及兴趣的减退、全身乏力、忧郁情绪、睡眠障碍等。抑郁的发生与性别、病程、UPDRSIII评分、Hoehn-Yahr分级有明显相关性,与年龄无显著相关性。治疗后HAMD评分明显降低,与治疗前比较,差异具有统计学意义。结论抑郁是帕金森病患者常见的伴发症状,其发生与性别、病程、UPDRSIII评分、Hoehn-Yahr分级有关,给予中西医结合治疗效果显著,可有效减轻抑郁症状。
Objective To investigate the clinical features, influencing factors, treatment methods and effects of depressive symptoms associated with Parkinson’s disease. Methods A total of 37 patients with Parkinson’s disease and depressive symptoms admitted to our hospital were enrolled in this study. The clinical data were analyzed retrospectively. The incidence and characteristics of depression, depression and age, gender, course of disease, UPDRSIII score and Hoehn-Yahr grading Of the correlation, the use of sertraline hydrochloride tablets combined with traditional Chinese medicine treatment, compared before and after treatment HAMD score changes. Results During the observation period, 37 of 86 patients with Parkinson’s disease had depressive symptoms, the incidence rate was 43.02%. The main manifestations were the decline of work and interest, generalized fatigue, depression, sleep disorders and so on. There was a significant correlation between depression and gender, disease course, UPDRSIII score and Hoehn-Yahr grade, but no significant correlation with age. HAMD score decreased significantly after treatment, compared with before treatment, the difference was statistically significant. Conclusions Depression is a common concomitant symptom in patients with Parkinson’s disease. The occurrence of depression is related to gender, course of disease, UPDRSIII score and Hoehn-Yahr classification. The combination of TCM and WM treatment is effective and can effectively reduce the symptoms of depression.