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目的研究抗衰老胶囊的药理作用。方法用复杂水迷路法测试小鼠的学习记忆状况。分别建立记忆获得障碍病理模型、记忆巩固障碍病理模型和记忆再现缺失病理模型。将抗衰老胶囊分散于鼠饲料中制成颗粒型,定量喂食,作为治疗模型。分别测定小鼠的用药后药物对外周血管与脑血管的扩张作用;和药物的抗衰老状况。结果抗衰老胶囊对记忆获得障碍有非常显著的治疗意义,治疗组与病理组(P<0.01),病理组与空白组(P<0.01)的差异有非常显著意义。对记忆再现缺失有非常显著意义,治疗组与病理组(P<0.01),病理组与空白组(P<0.01),治疗组与空白组(P<0.01)的差异有显著意义。结果表明抗衰老胶囊能扩张外周循环,脑内微循环,能减少小鼠脑部的脂褐质量。结论抗衰老胶囊能使小鼠提高学习记忆的能力,能扩张外周循环,能增加对脑部的供血量,减缓衰老程度。
Objective To study the pharmacological effects of anti-aging capsules. Methods The test of mice’s learning and memory was performed with complex water labyrinth method. The pathological model of memory acquisition disorder, the pathological model of memory consolidation disorder and the pathological model of lack of memory reproducibility were established. The anti-aging capsules were dispersed in mouse feed to make pellets and quantitatively fed as a therapeutic model. The effect of drug administration on the expansion of peripheral blood vessels and cerebrovascular vessels in mice was measured, and the anti-aging state of drugs was measured. Results Anti-aging capsules had a significant therapeutic effect on memory impairment. The difference between the treatment group and pathological group (P<0.01), pathological group and blank group (P<0.01) was very significant. The lack of memory reproducibility was significant in the treatment group and pathology group (P<0.01), pathology group and blank group (P<0.01), and between treatment group and blank group (P<0.01). The results show that anti-aging capsules can expand the peripheral circulation, microcirculation in the brain, can reduce the lipid brown quality of the mouse brain. Conclusion Anti-aging capsules can improve the ability of mice to learn and memory, expand the peripheral circulation, increase the blood supply to the brain, and reduce the degree of aging.