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目的：探讨胃的慢性炎症、肠上皮化生、异型增生、癌与ＤＮＡ指数（ＤＩ）及倍体分布的关系。方法：慢性胃炎３２例、肠上皮化生３１例、异型增生３４例、癌７３例，用多媒体彩色病理图文分析系统（ＭＰＩＡＳ－５００）测量各组病变细胞核ＤＩ值及倍体分布情况。结果：ＤＮＡ含量在各组病变胃粘膜中有显著差异（Ｐ＜０．００１）；倍体构成在慢性炎症、肠上皮化生、异型增生之间无显著差异（Ｐ＞０．０５），慢性炎症、肠上皮化生、异型增生与癌之间差异均有显著性（Ｐ＜０．０５）。结论：胃良、恶性病变细胞核ＤＮＡ含量及非整倍体细胞所占百分比不同。形态定量分析检测细胞核ＤＩ值及ＤＮＡ倍体分布，可作为胃良、恶性病变诊断和分类的辅助诊断，并有助于指导临床治疗和估计肿瘤的恶性潜能，以判断预后
Objective: To investigate the relationship between gastric chronic inflammation, intestinal metaplasia, dysplasia, cancer and DNA index (DI) and ploidy distribution. Methods: Chronic gastritis in 32 cases, intestinal metaplasia in 31 cases, dysplasia in 34 cases and carcinoma in 73 cases were measured by using MPIAS-500. The DI value and ploidy distribution in each group were measured. Results: The content of DNA in the gastric mucosa of each group was significantly different (P <0.001). There was no significant difference (P> 0.05) between the structure of the ploidy and chronic dysplasia, intestinal metaplasia and dysplasia (P> 0.05) Inflammation, intestinal metaplasia, dysplasia and cancer were significantly different (P <0.05). Conclusion: The contents of nuclear DNA and the percentage of aneuploid cells in gastric benign and malignant lesions are different. Quantitative morphometric analysis of nuclear DNA and DNA ploidy distribution can be used as gastric benign and malignant lesions diagnosis and classification of auxiliary diagnosis and help guide clinical treatment and malignant potential of the tumor to determine the prognosis