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血小板在止血和血栓形成过程中起着重要作用,血小板膜糖蛋白(GP)与血小板的功能有密切联系.国际上1980年开始有抗人血小板单克隆抗体的报道,1981年阮长耿等首次应用抗人血小板单克隆抗体AN_(51)阐明了血小板GPI作为VWF受体在初期止血中起重要作用。此后各国相继报道了一些单克隆抗体的产生和应用,对血小板膜的结构及其功能有了进一步的认识。我们于1983年应用杂交瘤技术在国内首次获得了14株分泌抗人血小板单克隆抗体的小鼠杂交瘤细胞株,并将其中两株即
Platelet plays an important role in the process of hemostasis and thrombosis, platelet glycoprotein (GP) and the function of platelets are closely linked .International anti-human platelet monoclonal antibody was reported in 1980, in 1981, Nguyen Chang Geng and other first application of anti- Human platelet monoclonal antibody AN_ (51) elucidated the important role of platelet GPI as a VWF receptor in primary hemostasis. Since then, various countries have reported the production and application of some monoclonal antibodies, and further understanding of the structure and function of platelet membranes. We used hybridoma technology in 1983 for the first time in China 14 strains of mouse hybridoma secreting anti-human platelet monoclonal antibodies, and two of them