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作者以短程中等剂量β和γ干扰素联合应用对20例慢性活动性乙型肝炎病人进行了随机对照治疗试验。患者男性17例,女性3例,年龄16～70岁。确定疾病活动性的诊断,除肝组织学检查外,主要根据肝细胞炎症和坏死的生化参数,或谷草转氨酶和谷丙转氨酶水平升高至少为正常值的2倍。在开始干扰素治疗前,大多数病人都经过数年的定期临床检查。这些病人的血清HBsAg、HBeAg和HBV DNA皆阳性,肝内有复制型HBV DNA。
The authors conducted a randomized controlled trial of 20 chronic active hepatitis B patients with a combination of short-term, moderate-dose beta and gamma interferon. There were 17 males and 3 females, aged from 16 to 70 years. The diagnosis of disease activity, in addition to liver histology, is based on biochemical parameters of hepatocyte inflammation and necrosis, or at least two times as much as normal levels of aspartate aminotransferase and glutamic-pyruvic transaminase. Most patients undergo several years of regular clinical examination before starting interferon therapy. These patients had positive serum HBsAg, HBeAg and HBV DNA, and replicative HBV DNA in the liver.