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多发性硬化(MS)的特征之一是CNS和CSF中出现免疫球蛋白(Ig)的异常。CNS中CSF和IgG含量增加,进行蛋白电泳时IgG的分布异常,出现单克隆带。Ig异常对于MS的病因机制的探讨是一个重要线索。通常认为Ig异常是与持久的抗原刺激和/或与免疫失调有关。作者为这些推测提供了证据,并设想Ig异常与B细胞的内在遗传异常有关。 MS Ig异常的发生机制持久的抗原刺激:据报道在许多慢性抗原刺激性疾病中出现IgG带。如在亚急性硬化性全脑炎(SSPE)病人CSF中可见此带;此带能与致病因子麻疹病毒发生直接反应。与SSPE不同,MS的CSF中多克隆IgG是增多的;这种多克隆IgG与单克隆IgG一样含有抗不同抗原的抗体,而不是对抗特殊的致病因子。作者发现在个别SSPE患者血清、CSF和脑
One of the hallmarks of multiple sclerosis (MS) is the presence of immunoglobulin (Ig) abnormalities in CNS and CSF. The content of CSF and IgG in CNS increased, and IgG was abnormally distributed during protein electrophoresis. Monoclonal bands appeared. Ig abnormalities for the etiology of MS is an important clue. Ig abnormalities are generally considered to be associated with persistent antigenic stimulation and / or with immune disorders. The authors provide evidence for these hypotheses and hypothesize that Ig abnormalities are associated with intrinsic genetic abnormalities in B cells. Mechanisms of MS Ig Abnormality Long-lasting antigenic stimulation: IgG bands have been reported to be present in many chronic antigen-stimulating diseases. This is seen in the CSF of patients with subacute sclerosing pan-encephalitis (SSPE); this band can react directly with the virulence factor measles virus. Unlike SSPE, there is an increase in polyclonal IgG in MS’s CSF; this polyclonal IgG, like monoclonal IgG, contains antibodies against different antigens rather than against specific virulence factors. The authors found serum, CSF and brain in individual SSPE patients