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Objectives To investigate the value of pregnancy-associated plasma protein-A (PAPP-A) and matrix metallo proteinase-9(MMP-9) in the diagnosis and outcomes evaluation of acute coronary syndrome (ACS) patient. Methods 100 ACS patients were divided into UAP group (64 cases) and AMI group (36 cases), and 50 healthy cases served as control group. The levels of PAPP-A, MMP-9, Hs-CRP, CK-MB and cTnI were obtained. The ACS patients with normal CK-MB and cTnI concentration were followed up. During 6 months, the total rates of major cardiovascular events (MACE) were recorded. Results Compared to control group, the PAPP-A, MMP-9, Hs-CRP, CK-MB, cTnI levels of ACS patients were significantly increased (P<0.01), but the levels of PAPP-A, MMP-9 did not correlate well with CK-MB and cTnI. The ACS patients with normal CK-MB and cTnI concentration were followed up 6 months, the levels of PAPP-A, MMP-9 were significantly associated with the MACE (P<0.01). Conclusions The levels of PAPP-A, MMP-9 of ACS patients were not associated with myocardial ischemic necrosis, but could serve as predictor of unstable atherosclerotic plaque, and as valuable index for prognosis monitoring in ACS patients.
Objectives To investigate the value of pregnancy-associated plasma protein-A (PAPP-A) and matrix metallo proteinase-9 (MMP-9) in the diagnosis and outcomes evaluation of acute coronary syndrome (ACS) patient. Methods 100 ACS patients were divided The UAP group (64 cases) and AMI group (36 cases), and 50 healthy cases served as control group. The levels of PAPP-A, MMP-9, Hs-CRP, CK-MB and cTnI were obtained. Results Compared to control group, the PAPP-A, MMP-9, Hs-CRP, CK- MB, cTnI levels of ACS patients were significantly increased (P <0.01), but the levels of PAPP-A, MMP-9 did not correlate well with CK-MB and cTnI. The ACS patients with normal CK-MB and cTnI concentration were followed up for 6 months, the levels of PAPP-A, MMP-9 were significantly associated with the MACE (P <0.01). Conclusions The levels of PAPP-A, MMP- atients were not associated with myocardial ischemic necrosis but could serve as predictor of unstable atherosclerotic plaque, and as valuable index for prognosis monitoring in ACS patients.