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目的对BMSCs在急性肺损伤(acute lung injury,ALI)中的基础研究、临床进展及其机制进行综述。方法查阅近年有关BMSCs在ALI中的基础研究及临床相关文献并进行综述。结果 BMSCs能主动归巢至肺损伤部位并通过分化参与组织修复,同时BMSCs能调节和平衡ALI时局部和全身炎性反应和免疫紊乱。目前BMSCs对ALI抗炎-免疫调节以及组织修复的机制尚不清楚。结论具有主动归巢、分化以及抗炎-免疫调节效应的BMSCs对ALI具有全面的生物学效应,有望应用于临床,也为ALI的基因-干细胞治疗奠定了基础。
Objective To summarize the basic research, clinical progress and mechanism of BMSCs in acute lung injury (ALI). Methods The basic research and clinical literature about BMSCs in ALI in recent years were reviewed and reviewed. Results BMSCs could spontaneously homing to the site of lung injury and participating in tissue repair through differentiation. At the same time, BMSCs can regulate and balance local and systemic inflammatory reaction and immune disorder during ALI. At present, the mechanism of BMSCs against ALI anti-inflammatory-immune regulation and tissue repair is not clear. Conclusion BMSCs with active homing, differentiation and anti-inflammatory-immunomodulatory effects have a comprehensive biological effect on ALI and are expected to be used clinically and lay the foundation for the gene-stem cell therapy of ALI.