论文部分内容阅读
凝血因子V Leiden(factor V Leiden,FVL)突变已明确为静脉血栓栓塞症(venous thromboembolism,VTE)的原发性危险因素~([1])。而肺栓塞(pulmonary embolism,PE)与深静脉血栓形成(deep venous thrombosis,DVT)一般被认为是一种疾病在不同部位、不同阶段的表现,两者合称为VTE~([2]),故认为FVL突变在DVT与PE中的发生率也是一样的。而FVL悖论的提出,让我们把这两种疾病当作不同的整体去重新考虑,也进一步去明确FVL悖论的机制及临床意义。1 FVL突变凝血因子V(factor V,FV)即血浆辅助因子,
The mutation of factor V Leiden (FVL) has been identified as a primary risk factor for venous thromboembolism (VTE). Pulmonary embolism (PE) and deep venous thrombosis (DVT) are generally considered as a manifestation of a disease at different sites and stages, both of which are collectively referred to as VTE ~ (2) Therefore, the incidence of FVL mutation in DVT and PE is also the same. The FVL paradox proposed, let us consider these two diseases as a whole to reconsider, but also to further clarify the mechanism of FVL paradox and clinical significance. 1 FVL mutant factor V (FV) that plasma co-factor,