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目的:探讨同期放化疗治疗中晚期鼻咽癌的疗效。方法:我院2003年6月至2006年10月中晚期鼻咽癌患者95例回顾分析,两组放射治疗相同,用6 MV-X线外照射和6～12 MeV电子线,观察组放疗始PF方案同步化疗。结果:两组治疗结束后3个月观察组鼻咽癌原发病灶疗效有效率高于对照组(P<0.05),颈部淋巴结疗效有效率高于对照组(P<0.05),两组患者不良反应主要为急性黏膜反应、骨髓抑制、胃肠道反应等。观察组的毒副作用发生率明显高于对照组(P<0.05)。结论:同期放化疗治疗中晚期(Ⅲ或Ⅳa期)鼻咽癌是目前较为理想的治疗方案,其毒性反应可以耐受。
Objective: To investigate the effect of concurrent chemoradiotherapy on advanced nasopharyngeal carcinoma. Methods: From June 2003 to October 2006 in our hospital, 95 patients with nasopharyngeal carcinoma were retrospectively analyzed. The radiotherapy was the same in both groups. The 6 MV-X external beam and 6 ~ 12 MeV electron beam were used to observe the radiotherapy PF regimen synchronous chemotherapy. Results: Three months after the end of treatment, the effective rate of primary tumor of NPC in observation group was higher than that of control group (P <0.05), and the effective rate of cervical lymph node was higher than that of control group (P <0.05) Adverse reactions mainly acute mucosal response, bone marrow suppression, gastrointestinal reactions. The incidence of toxic side effects in the observation group was significantly higher than that in the control group (P <0.05). Conclusions: The same period of radiotherapy and chemotherapy in the treatment of advanced stage (Ⅲ or Ⅳ a) nasopharyngeal carcinoma is an ideal treatment program, the toxicity can be tolerated.