Acrylamide Alters Cytoskeletal Protein Level in Rat Serum

• 作 者: YU Su Fang SONG Fu Ying YI Chao YANG Xi Wei LI Guo Zhen ZHANG Cui Li ZHAO Xiu Lan XIE Ke Qin
• 机 构: School of Public Health, Shandong University,Guangming New District CDC of Shenzhen,
• 出 处: Biomedical and Environmental Sciences
• 发表日期: 2013年11期

To study biomarker of acrylamide (ACR) induced neuropathy,Wistar rats received 20 or 40mg/kg of ACR by ip injection and the levels of light neurofilament (NF-L),middle NF (NF-M),heavy NF (NF-H),β-actin,α-tubulin,and β-tubulin proteins in serum were evaluated using both SDS-PAGE and Western blotting.Compared to controls,NF-L and NF-M decreased,howeverα-tubulin,β-tubulin,and β-actin increased (P<0.01).This result suggested that the change of these cytoskeletal proteins

To study biomarker of acrylamide (ACR) -mediated neuropathy, Wistar rats received 20 or 40 mg / kg of ACR by ip injection and the levels of light neurofilament (NF-L), middle NF (NF-M), heavy NF ), β-actin, α-tubulin, and β-tubulin proteins in serum were evaluated using both SDS-PAGE and Western blotting. Compared to controls, NF-L and NF- β-actin increased (P <0.01). This result suggests that the change of these cytoskeletal proteins