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目的观察肾细胞癌(简称肾癌)的临床流行病学特征,探讨其预后的相关影响因素。方法回顾性分析2003年1月～2011年12月121例肾癌患者行手术治疗的临床资料。采用Kaplan-Meier法对生存率进行描述,采用Log-rank单因素分析及COX多因素分析对预后因素进行评价,所有数据用SPSS17.0统计软件进行处理。结果肾癌患者术后1、3、5年总体生存率分别为94%、86%、70%,平均生存期为79.96个月。单因素分析显示,年龄、病理分级、TNM分期病理类型、淋巴结转移、静脉瘤栓、糖尿病、是否有症状这8项因素与预后有关(P均<0.05)。COX多因素分析显示,仅有病理分级、TNM分期、淋巴结转移、静脉瘤栓4项因素与肾癌的预后有关(P均<0.05)。结论病理分级、TNM分期等是肾癌预后的独立影响因素。
Objective To observe the clinical epidemiological features of renal cell carcinoma (RCC) and to explore the related influencing factors of prognosis. Methods The clinical data of 121 patients with renal cell carcinoma who underwent surgical treatment from January 2003 to December 2011 were analyzed retrospectively. The Kaplan-Meier method was used to describe the survival rate. Log-rank univariate analysis and COX multivariate analysis were used to evaluate the prognostic factors. All data were processed by SPSS17.0 statistical software. Results The overall survival rates at 1, 3 and 5 years after renal cell carcinoma were 94%, 86% and 70%, respectively. The mean survival time was 79.96 months. Univariate analysis showed that age, pathological grade, TNM staging, lymph node metastasis, venous thrombus, diabetes mellitus, and whether there were any symptoms were related to prognosis (all P <0.05). Cox multivariate analysis showed that only pathological grade, TNM stage, lymph node metastasis and venous thrombus were related to the prognosis of renal cell carcinoma (all P <0.05). Conclusion The pathological grade, TNM stage and so on are independent prognostic factors of renal cell carcinoma.