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目的:观察米索前列醇用于足月妊娠促宫颈成熟的有效性及安全性。方法:选择125例足月妊娠、有引产指征的孕妇,以25μg的米索前列醇置于阴道后穹隆,分析用药前后12 h的宫颈Bishop评分、临产情况、分娩方式、产后出血、对母婴的影响。结果:米索前列醇促宫颈成熟率达79.0%,用药至临产时间平均为(527±392.1)min,引产成功率为75.2%,有2例发生产后出血,未对产妇和婴儿造成不良影响。结论:小剂量米索前列醇是一种有效和安全的促宫颈成熟的引产药物,对母儿无明显不良影响。
Objective: To observe the efficacy and safety of misoprostol for cervical ripening during term pregnancy. Methods: A total of 125 pregnant women with full-term pregnancy and induced abortion were enrolled in this study. 25 μg of misoprostol was placed in the vaginal vault and the cervical Bishop score, labor status, mode of delivery, postpartum hemorrhage, The impact of the baby. Results: Misoprostol promoted the rate of cervical ripening 79.0%. The average time to medication was (527 ± 392.1) min. The success rate of induction of labor was 75.2%. There were 2 cases of postpartum hemorrhage without adverse effects on the mothers and infants. Conclusion: A small dose of misoprostol is an effective and safe method to induce cervical ripening and has no obvious adverse effect on maternal and child.