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目的探讨他汀类药物治疗早期糖尿病肾病的临床疗效。方法选择我院2009年02月至2011年02月间80例早期DN患者随机分为观察组和对照组。对照组给予常规治疗,观察组每晚加服辛伐他汀20mg。比较两组治疗前及治疗后3个月、6个月的CHO、TG、LDL-C和HDL-C和Scr、BUN、CRP和UAER等指标。结果治疗组Scr、CRP和UAER在治疗3个月和6个月后与治疗前相比明显下降,差异有统计学意义(P<0.05),治疗6个月后与治疗3个月时相比下降明显,差异有统计学意义(P<0.05)。治疗组CHO、LDL-C和HDL-C的在治疗3个月和6个月后与治疗前相比明显下降,差异有统计学意义(P<0.05)。结论他汀类药物在调节早期DN患者血脂的同时,能降低Scr、CRP和UAER水平,起到保护肾脏的作用。
Objective To investigate the clinical efficacy of statins in the treatment of early diabetic nephropathy. Methods Eighty patients with early DN in our hospital from February 2009 to February 2011 were randomly divided into observation group and control group. The control group given routine treatment, the observation group plus service simvastatin 20mg per night. The indexes of CHO, TG, LDL-C, HDL-C and Scr, BUN, CRP and UAER before treatment, 3 months and 6 months after treatment were compared between the two groups. Results The levels of Scr, CRP and UAER in the treatment group decreased significantly at 3 months and 6 months after treatment compared with those before treatment (P <0.05). Compared with the 3 months after treatment Decreased significantly, the difference was statistically significant (P <0.05). The levels of CHO, LDL-C and HDL-C in the treatment group decreased significantly at 3 months and 6 months after treatment compared with those before treatment, the difference was statistically significant (P <0.05). Conclusions Statins can reduce the levels of Scr, CRP and UAER while regulating the blood lipids in patients with early DN, and play a role in protecting the kidneys.