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目的:探讨胰岛素样生长因子1(IGF-1)、环氧化酶-2(COX-2)在宫颈病变组织中的表达及临床意义。方法:应用免疫组织化学(EnVisionTM)法分别检测IGF-1、COX-2在30例正常组织、30例宫颈鳞状上皮内瘤变组织和70例恶性病变组织中的表达情况。结果:在正常组织、宫颈鳞状上皮内瘤变组织及宫颈鳞状细胞癌组织中,IGF-1的表达阳性率分别为0、3.33%和61.43%,差异有统计学意义(χ2=51.68,P<0.01);在正常组织、宫颈鳞状上皮内瘤变组织及宫颈鳞状细胞癌组织中,COX-2的表达阳性率分别为0、6.67%和51.43%,差异有统计学意义(χ2=36.45,P<0.01)。IGF-1的表达与肿瘤大小、淋巴结转移、远处脏器转移、FIGO分期有关,差异均有统计学意义(P<0.05),但与年龄、组织学类型无关,差异无统计学意义(P>0.05);COX-2的表达与淋巴结转移、远处脏器转移、FIGO分期有关,差异均有统计学意义(P<0.05),但与肿瘤大小、年龄、组织学类型无关,差异无统计学意义(P>0.05)。IGF-1表达与COX-2表达呈显著正相关(r=0.64,P<0.01)。结论:IGF-1、COX-2在宫颈鳞状细胞癌组织中呈现过表达,检测两者的表达可在一定程度上反映患者的预后。
Objective: To investigate the expression and clinical significance of insulin-like growth factor 1 (IGF-1) and cyclooxygenase-2 (COX-2) in cervical lesions. Methods: The expressions of IGF-1 and COX-2 in 30 normal tissues, 30 cervical squamous intraepithelial neoplasia tissues and 70 malignant lesions tissues were detected by immunohistochemistry (EnVisionTM). Results: The positive rates of IGF-1 in normal tissues, cervical squamous intraepithelial neoplasia and cervical squamous cell carcinoma tissues were 0, 3.33% and 61.43%, respectively, with significant difference (χ2 = 51.68, P <0.01). The positive rates of COX-2 in normal tissues, cervical squamous intraepithelial neoplasia and cervical squamous cell carcinoma tissues were 0,6.67% and 51.43%, respectively, with significant difference (χ2 = 36.45, P <0.01). The expression of IGF-1 was correlated with tumor size, lymph node metastasis, distant organ metastasis, FIGO stage (P <0.05), but not with age and histological type (P > 0.05). The expression of COX-2 was correlated with lymph node metastasis, distant organ metastasis and FIGO stage (P <0.05), but not with tumor size, age and histological type Significance (P> 0.05). There was a significant positive correlation between IGF-1 expression and COX-2 expression (r = 0.64, P <0.01). Conclusion: IGF-1 and COX-2 are overexpressed in squamous cell carcinoma of the cervix. Detecting the expression of both may reflect the prognosis to a certain extent.