Main alkaloids of Rhizoma Coptidis improved palmitic acidinduced insulin resistance in HepG2 cells v

• 作 者: Ming Qu Ying Wang Shijie Cao Y
• 机 构: DepartmentofBiochemistry,TianjinStateKeyLaboratoryofModernChineseMedicine,SchoolofChineseMateriaMedi
• 出 处: 亚洲传统医药
• 发表日期: 2020年5期
• 关键词: Rhizoma Coptidis ALKALOIDS insulin resistance AMPK pathway MAPK pathway GLUT2
• 基金项目: supported by Technology Major Project of China“Key New Drug Creation and Manufacturing Program”(No.2017ZX09301012-001),the National Natural Science Foundation of China(No.20972098,No.81703776 and No.8

Rhizoma Coptidis,a traditional Chinese herbal medicine,has been used for treating diabetes for thousands of years.However,the molecular basis for this action has not been elucidated.In the present study,the effects of seven main alkaloids of Rhizoma Copti