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阻断犬冠脉左前降支90min后再灌注60min，发现较持续缺血150min其缺血区细胞内Ca~(2+)、Na~+增加，K~+、Mg~(2+)显著降低。室性心律失常发生率高。而在心肌缺血45min时经静脉给予穿心莲提取液，较对照组缺血区细胞内Ca~(2+)降低（P＜0.05），Na~+明显降低、K~+显著升高（P＜0.01），Mg~(2+)增加（P＜0.05）。室性心律失常发生率及严重程度较低。说明穿心莲提取液可以阻止心肌缺血─再灌注过程中细胞内Na~+、Ca~(2+)增加，K+、Mg~(2+)丢失。这可能是其减少再灌注性心律失常的重要机制之一。
After blocking the left anterior descending coronary artery for 90 min and then reperfusion for 60 min, it was found that intracellular Ca~(2+), Na~+ increased, and K~+, Mg~(2+) decreased significantly compared with continuous ischemia for 150 min. . The incidence of ventricular arrhythmias is high. The intravenous administration of extract of Andrographis paniculata at 45 min after myocardial ischemia was associated with a decrease in intracellular Ca~(2+) in the ischemic area of the control group (P<0.05), a marked decrease in Na~+, and a significant increase in K~+ (P< 0.01), Mg 2+ increased (P<0.05). The incidence and severity of ventricular arrhythmias are low. It shows that the extract of Andrographis paniculata can prevent myocardial ischemia--the increase of intracellular Na~+, Ca~(2+), loss of K+ and Mg~(2+) during reperfusion. This may be one of the important mechanisms for reducing reperfusion arrhythmia.