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暴露于紫外光下可引起红斑,如果暴露时间延长,则出现晒斑。有人发现,由于照射紫外线β(290—320nm)所引起红斑皮肤上前列腺素有所增加。众所周知非甾体抗炎药物(NSAID)可抑制前列腺素的合成,由此可以预见这类药物对防治紫外光照射会有效果。已发现单独应用消炎痛可减少皮肤充血、发热和疼痛感。就在照射前口服其它非甾体抗炎药物(如阿司匹林和布洛芬)可提高紫外诱发红斑的阈值和平均最小红斑剂量。为了研究局部使用氟联苯丙酸(flurbiprofen)对防治紫外线B照射的效果,作者在十一名健康志愿者进行了观察。先将药物配制成为1、2、3、4及5％的含有乙醇(19份)、丙二醇(19份)及二甲乙酰胺(二份)的溶液,受试者在标准条件下用紫外线β(260—320nm)照射,然后立即在照射的三个部位使用药物溶液,有一处仅应用一次,而其它两处1小时后应用第二次,再过1小时后,两处中有一处应用第三次。
Exposure to ultraviolet light can cause erythema, if exposure time is prolonged, sunburn occurs. It has been found that there is an increase in prostaglandin on erythematic skin caused by exposure to UVB (290-320 nm). It is well-known that non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the synthesis of prostaglandins, which can be predicted that these drugs will have an effect on the prevention and treatment of ultraviolet light irradiation. Indomethacin alone has been found to reduce skin congestion, fever and pain. Oral administration of other NSAIDs, such as aspirin and ibuprofen, just prior to irradiation increases the threshold for UV-induced erythema and the mean minimum erythema dose. In order to study the effect of topical flurbiprofen on the prevention and treatment of UVB irradiation, the authors observed eleven healthy volunteers. The drug was first formulated as a solution containing 1, 2, 3, 4 and 5% ethanol (19 parts), propylene glycol (19 parts) and dimethylacetamide (2 parts) 260-320nm) irradiation, and then immediately in the irradiation of the three parts of the drug solution, one applied only once, while the other two 1 hour after the second application, after an hour later, one in two applications third Times.