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目的探讨胆囊结石与胆囊癌变的关系。方法对收治的原发性胆囊癌48例,进行了组织病理学及临床资料回顾分析。结果胆囊癌合并胆囊结石28例,占58.3%,其中男性33.3%(7/21),女性37.0%(10/27)均明显高于胆结石自然发病率,并随年龄增长而呈增高趋势,50岁以上者22例(78.3%),各年龄组间有显著性差异。病理学结果显示,胆结石所致的粘膜异型增生可癌变。结论胆囊结石可诱发癌变,应施行选择性预防性胆囊切除术。
Objective To investigate the relationship between gallbladder stones and gallbladder carcinogenesis. Methods Forty-eight cases of primary gallbladder carcinoma admitted to our hospital were reviewed retrospectively by histopathology and clinical data. Results There were 28 cases of gallbladder carcinoma complicated with gallstones (58.3%), of which 33.3% (7/21) of males and 37.0% (10/27) of females were significantly higher than the natural incidence of gallstones and increased with age, There were 22 cases (78.3%) over the age of 50 with significant difference among all age groups. Pathological results show that gallstone-induced mucosal dysplasia can be cancerous. Conclusion Gallstone can induce carcinogenesis, and selective preventive cholecystectomy should be performed.