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目的:分析不同药物对重度外阴阴道假丝酵母菌病的治疗效果。方法:选取180例重度外阴阴道假丝酵母菌病患者,将其随机分为A、B、C三组各60例,A组患者应用咪康唑栓阴道用药,B组患者应用中药止带方,C组患者给予咪康唑栓和止带方联合阴道用药。比较三组患者停药1周及3个月后的临床疗效及真菌学疗效和复发率。结果:C组患者治疗1周及1个月后治愈率及总有效率均明显高于A组和B组两组患者(P均<0.05);C组患者治疗1周后真菌学治愈率明显高于A组和B组(P均<0.05);C组患者治疗3个月后真菌学复发率明显低于A组和B组(P均<0.05),差异均具有统计学意义。结论:咪康唑栓和止带方联合治疗对重度外阴阴道假丝酵母菌病临床效果好,较单一用药的治愈率、总有效率及真菌学治愈率均有所提高,且真菌学复发率显著降低,值得临床推广应用。
Objective: To analyze the curative effect of different drugs on severe vulvovaginal candidiasis. Methods: 180 cases of severe vulvovaginal candidiasis were selected and randomly divided into three groups A, B and C 60 cases each. The patients in group A received miconazole suppository vaginal medication. The patients in group B received traditional Chinese drug Zhifu Fang, C Group patients were given miconazole suppositories and stop-side vaginal medication. Three groups of patients were compared for 1 week and 3 months after the clinical efficacy and efficacy and recurrence rate of mycology. Results: The cure rate and total effective rate in group C were significantly higher than those in group A and group B after treatment for 1 week and 1 month (all P <0.05). The cure rate in group C was significantly higher after 1 week (P <0.05). The recurrence rate of mycosis in group C after 3 months treatment was significantly lower than that in group A and B (all P <0.05), the differences were statistically significant. Conclusion: The combination therapy of miconazole suppository and Zhidai Fang has a good clinical effect on severe vulvovaginal candidiasis. The cure rate, total effective rate and mycological cure rate of single vulvovaginal candidiasis are all improved, and the recurrence rate of mycology is significantly lower ,Worthy of clinical application.